History of LNT - Dr. Edward Calabrese Documentary

Edward J. Calabrese is a professor of toxicology at the University of Massachusetts School of Public Health and Health Sciences, Amherst. He has researched extensively in the area of host factors affecting susceptibility to pollutants.

Dr. Calabrese is the author of over 1,000 papers in scholarly journals, as well as more than 10 books, including Principles of Animal Extrapolation; Nutrition and Environmental Health, Vols. I and II; Ecogenetics; Multiple Chemical Interactions; Air Toxics and Risk Assessment; and Biological Effects of Low Level Exposures to Chemical and Radiation. Along with Mark Mattson (National Institutes of Health) he is a coeditor of the recently published book Hormesis: A Revolution in Biology, Toxicology and Medicine.

Calabrese has been a member of the US National Academy of Sciences and NATO Countries Safe Drinking Water committees and on the Board of Scientific Counselors for the Agency for Toxic Substances and Disease Registry (ATSDR). He also serves as chairman of the Biological Effects of Low Level Exposures (BELLE) and as director of the Northeast Regional Environmental Public Health Center at the University of Massachusetts. He was awarded the 2009 Marie Curie Prize for his body of work on hormesis. He was the recipient of the International Society for Cell Communication and Signaling-Springer award for 2010 and was awarded an Honorary Doctor of Science Degree from McMaster University in 2013. In 2014, he was awarded the Peter Beckmann Award from Doctors for Disaster Preparedness.

Over the past 20 years, Professor Calabrese has redirected his research to understanding the nature of the dose response in the low-dose zone and underlying adaptive explanatory mechanisms. Of particular note is that this research has led to important discoveries which indicate that the most fundamental dose response in toxicology and pharmacology is the hormetic-biphasic dose-response relationship. These observations are leading to a major transformation in improving drug discovery and development and in the efficiency of the clinical trial, as well as the scientific foundations for risk assessment and environmental regulation for radiation and chemicals.

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